Mairi McLean talks to Philip Rosenstiel, Institute of Clinical Molecular Biology, Christian-Albrechts University, Kiel, and Stefan Schreiber, University Hospital Schleswig-Holstein, Kiel, about their paper: mTNF reverse signalling induced by TNFα antagonists involves a GDF-1 dependent pathway: implications for Crohn’s disease.

Mairi McLean, Gut’s education editor, talks to Xavier Hébuterne, Department of Gastroenterology and Nutrition, Archet Hospital, Nice, and Jean-Frédéric Colombel, Universite Lille Nord de France, about their paper: Endoscopic improvement of mucosal lesions in patients with moderate to severe ileocolonic Crohn’s disease following treatment with certolizumab pegol.

Mairi McLean, Gut’s education editor, talks to Peter Banks, Division of Gastroenterology, Hepatology, and Endoscopy, Harvard Medical School, and Michael Sarr, Department of Surgery, Mayo Clinic, Rochester, about their revision of the Atlanta classification of acute pancreatitis.

See also:
Classification of acute pancreatitis—2012: revision of the Atlanta classification and definitions by international consensus

Gut’s education editor Mairi McLean talks to Peter Mannon, Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, and Walter Reinisch, Department of Medicine IV, Division Gastroenterology and Hepatology, Medical University of Vienna, about their research looking at interluekin 13 and its role in gut defence and inflammation.

See also:
Interleukin 13 and its role in gut defence and inflammation

Recent studies have identified mucosal healing as a key prognostic parameter in the management of inflammatory bowel diseases. In this podcast Mairi McLean, education editor for Gut, talks to Marcus Neurath from the University of Erlangen-Nuremberg, and Simon Travis from John Radcliffe Hospital in Oxford, about their systematic review of the clinical studies on mucosal healing. They discuss the effects of anti-inflammatory or immunosuppressive drugs, and the implications of mucosal healing for subsequent clinical management in patients with IBD.

See also:
Mucosal healing in inflammatory bowel diseases: a systematic review

The Bowel Cancer Screening Programme has now been operating in England for six years, so how effective has it been in terms of take-up and detection? A paper in Gut examines the outcomes, and education editor Mairi McLean talks to some of the authors to hear what they found.

See also:
Outcomes of the Bowel Cancer Screening Programme (BCSP) in England after the first 1 million tests

Mairi McLean (Gut’s education editor) discusses August’s editor’s choice paper, on NKT-associated hedgehog and osteopontin and their role in non-alcoholic fatty liver disease, with authors Anna Mae Diehl (chief, Division of Gastroenterology, Duke University), Wing-Kin Syn (head of Regeneration and Repair, Institute of Hepatology, London) and Steve Choi (assistant professor, Division of Gastroenterology, Duke University).

See also:
NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

Gut microbiota has profound effects on host physiology, but local host–microbial interactions in the gut are only poorly characterised. Mairi McLean (Gut’s education editor) talks to Fredrik Bäckhed (Wallenberg Laboratory, Sahlgrenska University Hospital, Gothenburg, Sweden) about his study examining host responses induced by gut microbiota along the length of the gut, and whether these require the adaptor molecule MyD88.

See also:
Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88 -

Mairi Mclean (Gut education editor) talks to Maria Rescigno (European Institute of Oncology, Milan) about her editor’s choice paper - Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model.

Gut education editor Mairi Mclean talks to Dr Shuji Ogino, from Harvard Medical School, about his paper on the asessment of colorectal cancer molecular features.

See also:
Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum