This issue we look at short-term outcomes used to assess multiple sclerosis treatments, and their power to predict long-term disability, with Douglas Goodin (professor of clinical neurology, University of California, San Francisco).

We return to the association between cerebral amyloid angiopathy and intracerebral haemorrhage, as Neshika Samarasekera (Division of Clinical Neurosciences, University of Edinburgh) talks us through her research examining the link.

And Angela Vincent (emeritus professor at the Nuffield Department of Clinical Neurosciences, University of Oxford) looks back at the beginning of her career investigating autoantibodies in neurological diseases.

See also:
Relationship between early clinical characteristics and long term disability outcomes: 16 year cohort study (follow-up) of the pivotal interferon β-1b trial in multiple sclerosis
The association between cerebral amyloid angiopathy and intracerebral haemorrhage: systematic review and meta-analysis
Acetylcholine receptor antibody as a diagnostic test for myasthenia gravis: results in 153 validated cases and 2967 diagnostic assays

This month, cerebral amyloid angiopathy. David Werring (Stroke Research Group, UCL Institute of Neurology and the National Hospital for Neurology and Neurosurgery) discusses the importance of detecting it, especially as he feels it is under-recognised by physicians.

What impact does a healthy lifestyle have on mortality following stroke? Amytis Towfighi (Division of Stroke and Critical Care, Department of Neurology, University of Southern California) tells us what her research found.

And lastly, another dig into the JNNP archives. Mark Hallett (chief of the Human Motor Control Section at the US National Institute of Neurological Disorders and Stroke, NIH) has looked back on his early research on patterns of motor control for the third of our impact commentaries. He talks about how this opened a window onto movement disorder pathophysiology.

See also:
Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum
Impact of a healthy lifestyle on all-cause and cardiovascular mortality after stroke in the USA
EMG analysis of stereotyped voluntary movements in man